Deoxyuridine suppression test in cobalamin deficiency [letter]

Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency.

In vitro, deoxyuridine (dU) failed to block the incorporation of 3H-thymidine into bone marrow from 11 cases of vitamin B,2 deficiency, 6 cases of folate deficiency, an’i 3 cases of combined deficiency, even in patients without overt anemia, macrocytosis, and/or megaloblastosis. Different folate and cobalamin compounds had different effects on the incorporation of 3H-thymidine in the two defici...

deoxyuridine suppression test . New micro method for

The deoxyuridine suppression (dU) test measures the effect of deoxyuridine in suppressing the uptake of radioactively labelled tritiated thymidine into DNA and is specifically abnormal in vitamin B12 or folate deficiency, or when the metabolism of these is disturbed. The test is based on the observation that bone marrow cells from patients deficient in vitamin B12 incorporated much more thymidi...

Detection of folate deficiency in alcoholism using the peripheral blood lymphocyte deoxyuridine suppression test.

Twenty-seven alcoholic patients were studied for folate status. Twenty-two (81%) had neutrophil hypersegmentation and were detected as folate deficient by also having low serum folate, erythrocyte folate, lymphocyte folate and/or an abnormal peripheral blood lymphocyte deoxyuridine suppression test. Seventeen (63%) had an abnormal lymphocyte deoxyuridine suppression test and all 17 were correct...

Assessment of deoxyuridine suppression test in diagnosis of vitamin B12 or folate deficiency.

Deoxyuridine (dU) suppression tests have been performed on virtually all marrow samples aspirated at this hospital over the past 12 months. Of the 110 samples studied 26 gave abnormal results, and these 26 samples came from patients deficient in either vitamin B(12) or folate. The dU suppression test was found to be of particular value in the diagnosis of vitamin B(12) or folate deficiency in n...

Diagnosis of cobalamin deficiency.